INTOXICATE

Which Poisoned Patients Need the ICU?

Background.

1. Fraction of poisoned patients each year admitted to ICU/Stepdown
2. Physiology of poisoning means that scoring systems meant to determine general illness like APACHE may not work.
3. X previously developed INTOXICATE with methods that had results.

Project Roadmap

graph LR
    A[Replicate Study in US] --> B[Refine Predictors] & C[Extend to Childrens]
    B --> D[Prospectively Validate]
    B --> E[Prospectively Validate]

(Brandenburg et al., 2017) Developed INTOXICATE to determine which poisoned patients need admission to the ICU/Stepdown unit. Below is the model. SBPS refers to systolic blood pressure. EMV refers to the Glasgow Coma Scale (eye, motor, verbal).

$$ \textrm{risk} = \begin{bmatrix} -1.75 \\ -0.91398 \\ 0.25399 \\ 0.061925 \\ 0.162626 \\ -0.265 \\ -1.22151 \\ 0.325561 \\ 0.038357 \\ 0.014 \\ -0.02035 \\ -0.164725 \\ 1.527795 \\ 1.423788 \\ 0.983364 \\ 1.289260 \\ \end{bmatrix} \cdot \begin{bmatrix} 1 \\ \textrm{alcohol} \\ \textrm{analgesic}\\ \textrm{antidepressant}\\ \textrm{street drug}\\ \textrm{sedative}\\ \textrm{poison}\\ \textrm{other}\\ \textrm{Age}\\ \textrm{Pulse}\\ \textrm{SBP}\\ \textrm{EMV}\\ \textrm{Respiratory insufficiency}\\ \textrm{Cirrhosis}\\ \textrm{Dysrhythmia}\\ \textrm{Second reason of ICU admission}\\ \end{bmatrix} $$

There is before bort.

And after bort.

References

1. 1.Brandenburg, R. et al. The need for ICU admission in intoxicated patients: a prediction model. Clinical toxicology 55, 4–11 (2017).